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hrp0095p1-375 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Effects of long-term puberty suppression and gender-affirming hormones on body composition and metabolic profile in a preclinical mouse model and a cohort of transboys

Dubois Vanessa , Ciancia Silvia , Claessens Frank , Craen Margarita , El Kharraz Sara , Kim Nari , Klink Daniel , Sommers Vera , Vanderschueren Dirk , Cools Martine

Background: The increasing number of transgender adolescents presenting in early puberty requires to investigate the effects of long-term puberty suppression and gender-affirming hormones (GAH) on body composition and metabolism. Clinical studies have ethical and practical limitations. A preclinical mouse model may be helpful to gain mechanistic insights.Methods: Prepubertal (4week-old) female mice were treated with the ...

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Effects of long-term puberty suppression and gender-affirming hormones on body composition and metabolic profile in a preclinical mouse model and a cohort of transboys

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